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Leukemia, chronic lymphocytic, susceptibility to, 2(DBM; BCLL)

MedGen UID:
358385
•Concept ID:
C1868683
•
Finding
Synonyms: B-CELL MALIGNANCY, LOW-GRADE; DISRUPTED IN B-CELL MALIGNANCY; Leukemia, chronic lymphocytic 2
 
Monarch Initiative: MONDO:0007190
OMIM®: 109543

Clinical features

From HPO
B-cell chronic lymphocytic leukemia
MedGen UID:
44120
•Concept ID:
C0023434
•
Neoplastic Process
Chronic lymphocytic leukemia (CLL) is a common neoplasia of B lymphocytes in which these cells progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival (summary by Quesada et al., 2012). Genetic Heterogeneity of Susceptibility to Chronic Lymphocytic Leukemia Susceptibility loci have been mapped to chromosomes 11p11 (CLLS1; 609630) and 13q14 (CLLS2; 109543) by genomewide linkage analysis and translocation studies, respectively. Susceptibility mapping to chromosome 9q34 (CLLS3; 612557) is associated with downregulation of the DAPK1 gene (600831). Genomewide association studies have identified susceptibility loci on chromosomes 6p25.3 (CLLS4; 612558) and 11q24.1 (CLLS5; 612559).
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Professional guidelines

PubMed

Omicron related COVID-19 prevention and treatment measures for patients with hematological malignancy and strategies for modifying hematologic treatment regimes.
Guo W, Zheng Y, Feng S
Front Cell Infect Microbiol 2023;13:1207225. Epub 2023 Oct 19 doi: 10.3389/fcimb.2023.1207225. PMID: 37928188Free PMC Article
Venetoclax for the Treatment of Chronic Lymphocytic Leukemia.
Eradat H
Curr Hematol Malig Rep 2019 Oct;14(5):469-476. doi: 10.1007/s11899-019-00539-3. PMID: 31512151
Distribution of rs2124594 genotypes in chronic lymphocytic leukemia patients depending on radiation anamnesis.
Bilous NI, Abramenko IV, Chumak AA, Diagil IS, Martina ZV
Probl Radiac Med Radiobiol 2017 Dec;22:323-331. PMID: 29286517

Recent clinical studies

Etiology

Novel Therapies in Chronic Lymphocytic Leukemia: A Rapidly Changing Landscape.
Iovino L, Shadman M
Curr Treat Options Oncol 2020 Mar 13;21(4):24. doi: 10.1007/s11864-020-0715-5. PMID: 32170458
Venetoclax for the Treatment of Chronic Lymphocytic Leukemia.
Eradat H
Curr Hematol Malig Rep 2019 Oct;14(5):469-476. doi: 10.1007/s11899-019-00539-3. PMID: 31512151
Chronic lymphocytic leukaemia.
Hallek M, Shanafelt TD, Eichhorst B
Lancet 2018 Apr 14;391(10129):1524-1537. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(18)30422-7. PMID: 29477250
Chronic lymphocytic leukemia.
Shanshal M, Haddad RY
Dis Mon 2012 Apr;58(4):153-67. doi: 10.1016/j.disamonth.2012.01.009. PMID: 22449365
Legionella and immunosuppression.
Schlossberg D, Bonoan J
Semin Respir Infect 1998 Jun;13(2):128-31. PMID: 9643390

Diagnosis

Chronic Lymphocytic Leukemia.
Chiorazzi N, Chen SS, Rai KR
Cold Spring Harb Perspect Med 2021 Feb 1;11(2) doi: 10.1101/cshperspect.a035220. PMID: 32229611Free PMC Article
Novel Therapies in Chronic Lymphocytic Leukemia: A Rapidly Changing Landscape.
Iovino L, Shadman M
Curr Treat Options Oncol 2020 Mar 13;21(4):24. doi: 10.1007/s11864-020-0715-5. PMID: 32170458
Prospects for Venetoclax in Myelodysplastic Syndromes.
Garcia JS
Hematol Oncol Clin North Am 2020 Apr;34(2):441-448. Epub 2019 Dec 11 doi: 10.1016/j.hoc.2019.10.005. PMID: 32089221
Chronic lymphocytic leukaemia.
Hallek M, Shanafelt TD, Eichhorst B
Lancet 2018 Apr 14;391(10129):1524-1537. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(18)30422-7. PMID: 29477250
Chronic lymphocytic leukemia.
Shanshal M, Haddad RY
Dis Mon 2012 Apr;58(4):153-67. doi: 10.1016/j.disamonth.2012.01.009. PMID: 22449365

Therapy

COVID-19 and Chronic Lymphocytic Leukemia: Where We Stand Now.
Chatzikonstantinou T, Herishanu Y, Montserrat E, Ghia P, Cuneo A, Foà R, Scarfò L
Cancer J 2021 Jul-Aug 01;27(4):328-333. doi: 10.1097/PPO.0000000000000535. PMID: 34398560
Prospects for Venetoclax in Myelodysplastic Syndromes.
Garcia JS
Hematol Oncol Clin North Am 2020 Apr;34(2):441-448. Epub 2019 Dec 11 doi: 10.1016/j.hoc.2019.10.005. PMID: 32089221
Chronic lymphocytic leukaemia.
Hallek M, Shanafelt TD, Eichhorst B
Lancet 2018 Apr 14;391(10129):1524-1537. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(18)30422-7. PMID: 29477250
Familial leukemias.
Wiernik PH
Curr Treat Options Oncol 2015 Feb;16(2):8. doi: 10.1007/s11864-014-0323-3. PMID: 25762123
Chronic lymphocytic leukemia.
Shanshal M, Haddad RY
Dis Mon 2012 Apr;58(4):153-67. doi: 10.1016/j.disamonth.2012.01.009. PMID: 22449365

Prognosis

Chronic Lymphocytic Leukemia.
Chiorazzi N, Chen SS, Rai KR
Cold Spring Harb Perspect Med 2021 Feb 1;11(2) doi: 10.1101/cshperspect.a035220. PMID: 32229611Free PMC Article
Novel Therapies in Chronic Lymphocytic Leukemia: A Rapidly Changing Landscape.
Iovino L, Shadman M
Curr Treat Options Oncol 2020 Mar 13;21(4):24. doi: 10.1007/s11864-020-0715-5. PMID: 32170458
Chronic lymphocytic leukaemia.
Hallek M, Shanafelt TD, Eichhorst B
Lancet 2018 Apr 14;391(10129):1524-1537. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(18)30422-7. PMID: 29477250
Familial leukemias.
Wiernik PH
Curr Treat Options Oncol 2015 Feb;16(2):8. doi: 10.1007/s11864-014-0323-3. PMID: 25762123
Chronic lymphocytic leukemia.
Shanshal M, Haddad RY
Dis Mon 2012 Apr;58(4):153-67. doi: 10.1016/j.disamonth.2012.01.009. PMID: 22449365

Clinical prediction guides

Epidemiology of Chronic Lymphocytic Leukemia in Sardinia, Italy (1974-2003).
Broccia G, Carter J, Ozsin-Ozler C, De Matteis S, Cocco P
Exp Hematol 2023 Sep-Oct;125-126:37-44. Epub 2023 Aug 9 doi: 10.1016/j.exphem.2023.08.002. PMID: 37567460
BCL-2 expression promotes immunosuppression in chronic lymphocytic leukemia by enhancing regulatory T cell differentiation and cytotoxic T cell exhaustion.
Liu L, Cheng X, Yang H, Lian S, Jiang Y, Liang J, Chen X, Mo S, Shi Y, Zhao S, Li J, Jiang R, Yang DH, Wu Y
Mol Cancer 2022 Feb 22;21(1):59. doi: 10.1186/s12943-022-01516-w. PMID: 35193595Free PMC Article
The Pivotal Role of Viruses in the Pathogeny of Chronic Lymphocytic Leukemia: Monoclonal (Type 1) IgG K Cryoglobulinemia and Chronic Lymphocytic Leukemia Diagnosis in the Course of a Human Metapneumovirus Infection.
Barben J, Putot A, Mihai AM, Vovelle J, Manckoundia P
Viruses 2021 Jan 16;13(1) doi: 10.3390/v13010115. PMID: 33466993Free PMC Article
Immune Dysfunctions and Immune-Based Therapeutic Interventions in Chronic Lymphocytic Leukemia.
Griggio V, Perutelli F, Salvetti C, Boccellato E, Boccadoro M, Vitale C, Coscia M
Front Immunol 2020;11:594556. Epub 2020 Nov 18 doi: 10.3389/fimmu.2020.594556. PMID: 33312177Free PMC Article
Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030

Recent systematic reviews

Meat, fish, dairy products and risk of hematological malignancies in adults - a systematic review and meta-analysis of prospective studies.
Sergentanis TN, Ntanasis-Stathopoulos I, Tzanninis IG, Gavriatopoulou M, Sergentanis IN, Dimopoulos MA, Psaltopoulou T
Leuk Lymphoma 2019 Aug;60(8):1978-1990. Epub 2019 Mar 26 doi: 10.1080/10428194.2018.1563693. PMID: 30912696
Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.
Benna C, Helfrich-Förster C, Rajendran S, Monticelli H, Pilati P, Nitti D, Mocellin S
Oncotarget 2017 Apr 4;8(14):23978-23995. doi: 10.18632/oncotarget.15074. PMID: 28177907Free PMC Article
Risk of Atrial Fibrillation and Bleeding Diathesis Associated With Ibrutinib Treatment: A Systematic Review and Pooled Analysis of Four Randomized Controlled Trials.
Yun S, Vincelette ND, Acharya U, Abraham I
Clin Lymphoma Myeloma Leuk 2017 Jan;17(1):31-37.e13. Epub 2016 Sep 19 doi: 10.1016/j.clml.2016.09.010. PMID: 27780690
Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis.
Sava GP, Speedy HE, Houlston RS
Leuk Lymphoma 2014 Jan;55(1):160-7. Epub 2013 Jun 24 doi: 10.3109/10428194.2013.800197. PMID: 23647060

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